We provide research and project management support to advance small molecule programs from early-lead to Phase one clinical trials. We leverage our internal resources in conjunction with the resources of our network of  in vitro pharmacology, ADME, toxicology and pharmaceutics CROs to provide support for our partners.

What we offer:

HIGH QUALITY

We operate seamlessly with our partners as part of a unified research team to provide support from an experienced team of professionals with a successful track record of advancing projects from drug discovery into clinical trials

TIME EFFICIENCY

Reduce the time that it takes to achieve project milestones by leveraging an integrated and experienced drug discovery team working in combination with a network of trusted strategic partners and consultants

COST EFFECTIVENESS

By sharing the overhead costs of building and maintaining a state-of-the-art research facility

Services:

CHEMISTRY

Lead optimization, multigram compound synthesis for preclinical activities, synthesis of tools and benchmark molecules

DMPK

In vitro and in vivo pharmacokinetic determination, metabolism ID, CYP inhibition

PERSONALIZED PROJECT MANAGEMENT 

Discussion and implementation of research plans, including target product profiles, optimization flowcharts, and intellectual property strategy

QUANTITATIVE BIOLOGY

Assay optimization and automation compound optimization support

STRUCTURAL BIOLOGY/

COMPUTATIONAL CHEMISTRY

X-ray crystal structure elucidation, docking and QSAR

Equipped with state of the art analytical instrumentation housed in 7,000 square feet of laboratory space in South San Francisco, including 2 chemistry laboratories with a total of

11X8-foot hoods and an in vitro pharmacology/biology laboratory